Key result
VV ECMO achieves ~68% overall survival in severe refractory acute respiratory failure.
Why the study?
This study evaluated institutional experience with veno-venous ECMO in patients with severe acute respiratory failure due to various causes that were refractory to mechanical ventilation with conventional therapy.
What are the survival outcomes and prognostic factors associated with veno-venous extracorporeal membrane oxygenation (VV ECMO) in patients with severe acute respiratory failure refractory to conventional mechanical ventilation?
Cohort (n=31)
No
What are the survival outcomes and prognostic factors associated with veno-venous extracorporeal membrane oxygenation (VV ECMO) in patients with severe acute respiratory failure refractory to conventional mechanical ventilation?
Answers are grounded in this paper and cite their sources.
Early initiation of veno-venous ECMO in patients with severe refractory acute respiratory failure yielded a 68% overall survival rate and a 94% survival rate in trauma patients, highlighting the importance of rapid ECMO deployment before prolonged mechanical ventilation.
PURPOSE: The objective of this study was to evaluate our institutional experience with veno-venous (VV) extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory failure (ARF). MATERIALS AND METHODS: From January 2007 to August 2013, 31 patients with severe ARF that was due to various causes and refractory to mechanical ventilation with conventional therapy were supported with VV ECMO. A partial pressure of arterial oxygen (PaO₂)/inspired fraction of oxygen (FiO₂) <100 mm Hg at an FiO₂ of 1.0 or a pH <7.25 due to CO₂ retention were set as criteria for VV ECMO. RESULTS: Overall, 68% of patients survived among those who had received VV ECMO with a mean PaO₂/FiO₂ of 56.8 mm Hg. Furthermore, in trauma patients, early use of ECMO had the best outcome with a 94% survival rate. CONCLUSION: VV ECMO is an excellent, life-saving treatment option in patients suffering from acute and life-threatening respiratory failure due to various causes, especially trauma, and early use of VV ECMO therapy improved outcomes in these patients.
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Lee et al. (2014) conducted a cohort in Severe acute respiratory failure refractory to mechanical ventilation and conventional therapy (n=31). Veno-venous extracorporeal membrane oxygenation (VV ECMO) was evaluated on Overall survival. Veno-venous ECMO achieved a 68% overall survival rate in 31 patients with severe refractory acute respiratory failure, and a 94% survival rate among trauma patients.
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