Polycystic liver and kidney disease in internal medicine practice

This article presents a clinical case of a 58-year-old female patient with hereditary polycystic kidney and liver disease complicated by stage IV chronic kidney disease. The disease followed a progressive course: from the detection of renal cysts during reproductive age to the development of multisystem involvement, including severe renal dysfunction, hepatobiliary disorders, and secondary cardiovascular complications by the time of admission to the “DOC University Clinic.” Laboratory and instrumental investigations revealed extensive cystic transformation of the parenchyma, azotemia, signs of cholestasis, and multifocal atherosclerosis. A comprehensive personalized treatment approach led to stabilization of the patient’s condition, improvement in quality of life, and relief of symptoms. This case highlights the systemic nature of polycystic disease, as well as the importance of early diagnosis and an interdisciplinary approach to management.