Key result
Intravenous ceftriaxone (2 g daily for a planned 6-week course) resolved fever and reduced inflammatory markers without valve surgery in a 79-year-old man with Gemella haemolysans TAVR endocarditis.
Why the study?
Gemella haemolysans is an uncommon cause of infective endocarditis, and infection involving a prosthetic valve can be accompanied by extensive extracardiac disease.
Case Report (n=1)
No
This case demonstrates that Gemella haemolysans TAVR-associated prosthetic-valve endocarditis can cause extensive extracardiac complications—including multilevel vertebral osteomyelitis, epidural and psoas abscesses, and splenic infarction—despite a small (0.6 cm) valvular vegetation, and can be managed medically with prolonged intravenous ceftriaxone in poor surgical candidates.
Answers are grounded in this paper and cite their sources.
May support ceftriaxone monotherapy in select nonsurgical TAVR endocarditis cases; hypothesis-generating and requires prospective validation.
Gemella haemolysans is an uncommon cause of infective endocarditis, yet infection involving a prosthetic valve may be accompanied by extensive extracardiac disease. A 79‐year‐old man with a history of transcatheter aortic valve replacement presented with fever, rigors, dyspnea, severe low back pain, and inability to walk after a fall. Two sets of blood cultures grew G. haemolysans . Echocardiography demonstrated a 0.6 × 0.6 cm vegetation at the aortic valve annulus. Lumbar magnetic resonance imaging identified discitis and vertebral osteomyelitis at L4–L5 and L5–S1, an anterior epidural abscess, and moderate‐to‐severe spinal canal stenosis. Abdominal imaging revealed a right psoas abscess and a 6.2‐cm splenic infarction. Antimicrobial therapy was narrowed to intravenous ceftriaxone according to susceptibility testing. Fever resolved and inflammatory markers declined during hospitalization; a 6‐week course was arranged at discharge without valve surgery. This case highlights the association between endocarditis and vertebral infection, the limitations of vegetation size as a measure of extracardiac disease, and the complexity of treatment decisions following transcatheter valve replacement.
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Baghdasaryan et al. (2026) conducted a case report in Gemella haemolysans prosthetic-valve infective endocarditis following transcatheter aortic valve replacement (TAVR) (n=1). Intravenous ceftriaxone was evaluated on Resolution of fever and decline in inflammatory markers without valve surgery. Intravenous ceftriaxone (2 g daily for a planned 6-week course) resolved fever and reduced inflammatory markers without valve surgery in a 79-year-old man with Gemella haemolysans TAVR endocarditis.
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