Key result
High salt intake induces ~2-fold higher proteinuria in male versus female rats despite similar blood pressure.
Why the study?
Whether changes in blood pressure and proteinuria during chronic salt intake exhibit sex disparities in Sprague-Dawley rats was examined.
Does a high salt diet (8% NaCl) induce sex-specific differences in systolic blood pressure and proteinuria in Sprague-Dawley rats?
Does a high salt diet (8% NaCl) induce sex-specific differences in systolic blood pressure and proteinuria in Sprague-Dawley rats?
In Sprague-Dawley rats, high dietary salt induces significantly greater proteinuria in males than females independently of blood pressure changes, suggesting sex-specific susceptibility to salt-induced renal injury.
Answers are grounded in this paper and cite their sources.
High salt may induce greater proteinuria in males than females independent of BP; hypothesis-generating for sex differences in human renal injury.
We examined if changes in blood pressure and proteinuria during chronic salt intake exhibit sex disparities in age‐matched male (♂; N=10) and female (♀; N=10) Sprague‐Dawley (SD) rats subjected to either normal (0.7% NaCl) or high salt (8% NaCl) diets for 2‐weeks. Metabolic studies, systolic blood pressures (SBP) measured by tail‐cuff method and proteinuria in 24‐h urine samples, were performed. Baseline SBP was not different between genders (♂:119.1±3 vs. ♀:119.0±4 mmHg) or after 2‐weeks on HS diet (♂:129.0±5 vs. ♀:125.6±6 mmHg). HS intake induced proteinuria in both sexes; however it was greater in male than in female rats [Day ‐1(♂:5±1 vs. ♀:3±1); Day 9 (♂:36±3 vs. ♀:17±2 mg/day); p<0.01]. By day 13, body weights were higher in ♂ than ♀ rats; however there was no difference with salt load [(male NS: 330±8 versus male HS: 324±7 g); ♀ NS: 217±12 vs. ♀ HS: 226±4 g)]. There were no sex dependent differences in food intake after it factored by body weight (♂ NS: 11±1 g/kg BW; ♂ HS: 12±1 g/kg BW; female NS: 11±2 g/kg BW; female HS: 13±1 g/kg BW; p=no significant). SBP under HS intake did not exhibit sexual dimorphism; however the augmented proteinuria in male rats may reflect a greater predisposition to develop renal injury with high salt consumption than female rats. Grants from the APS (2009 Frontiers in Physiology Research Host Awardees Program); NIH (P20‐RR‐017659; Tulane‐BIRCWH K12HD043451 award).
No takes yet. Share an insight, caveat, or question.
Byrd et al. (2010) studied Proteinuria and systolic blood pressure response to high salt intake in Sprague-Dawley rats (n=20). High salt diet vs. Normal salt diet (0.7% NaCl) and sex comparison (male vs. female) was evaluated on Proteinuria in 24-hour urine samples at Day 9 (mg/day) and systolic blood pressure at 2 weeks (p=<0.01). High salt intake induced greater proteinuria in male than female rats at Day 9 without sex differences in systolic blood pressure.
Synapse has enriched 10 related papers. Consider them for comparative context: