Key result
Meta-analysis evaluates Lp(a) association with angiographic CAD severity in ACS without reported quantitative results.
Why the study?
The consistency and strength of the relationship between circulating lipoprotein(a) concentrations and angiographic coronary disease severity and complexity in adults presenting with ACS required clarification.
Are elevated circulating lipoprotein(a) concentrations associated with greater angiographic severity and complexity of coronary artery disease in adults presenting with acute coronary syndrome?
Meta-Analysis
Are elevated circulating lipoprotein(a) concentrations associated with greater angiographic severity and complexity of coronary artery disease in adults presenting with acute coronary syndrome?
Answers are grounded in this paper and cite their sources.
This systematic review and meta-analysis aims to clarify the association between circulating lipoprotein(a) levels and angiographic coronary disease burden and complexity in patients presenting with acute coronary syndrome.
This project is a systematic review and meta-analysis evaluating the association between circulating lipoprotein(a) [Lp(a)] concentrations and the angiographic severity and complexity of coronary artery disease in adults presenting with acute coronary syndrome (ACS), including STEMI, NSTEMI, and unstable angina. The review examines whether higher Lp(a) levels are associated with greater coronary disease burden as assessed by invasive coronary angiography, including multivessel or three-vessel disease, SYNTAX score, Gensini score, left main involvement, stenosis severity, lesion burden, chronic total occlusion, diffuse disease, and other measures of coronary anatomic complexity. The review includes observational studies identified through searches of PubMed, Ovid MEDLINE, Embase, and Web of Science and synthesizes findings according to major angiographic outcome categories. The purpose of the review is to clarify the consistency and strength of the relationship between Lp(a) and coronary anatomic burden in ACS and to identify methodological limitations and areas requiring further investigation. The expected outcome is a comprehensive synthesis of the available evidence that characterizes the relationship between Lp(a) and angiographic coronary disease burden and identifies priorities for future research.
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Jamai et al. (2026) conducted a meta-analysis in Acute coronary syndrome (STEMI, NSTEMI, and unstable angina). Elevated circulating lipoprotein(a) [Lp(a)] concentrations vs. Lower circulating lipoprotein(a) [Lp(a)] concentrations was evaluated on Angiographic severity and complexity of coronary artery disease (including multivessel/three-vessel disease, SYNTAX score, Gensini score, left main involvement, stenosis severity, lesion burden, chronic total occlusion, and diffuse disease). Circulating lipoprotein(a) is being evaluated for its association with angiographic coronary artery disease severity in acute coronary syndrome; no quantitative results are reported.
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