Key result
High triglyceride-glucose index linked to higher 5-year MACE risk after double-stent strategy.
Why the study?
Coronary artery bifurcation lesions carry an unfavorable long-term prognosis, and although the triglyceride-glucose index (TyGi) provides prognostic information in CAD, its ability to predict five-year MACEs specifically in patients with bifurcation lesions undergoing a double-stent strategy needed to be determined.
Does an elevated triglyceride-glucose index predict major cardiovascular events over 5 years in patients with coronary bifurcation lesions undergoing a double-stent strategy?
Cohort (n=552)
Does an elevated triglyceride-glucose index predict major cardiovascular events over 5 years in patients with coronary bifurcation lesions undergoing a double-stent strategy?
An elevated triglyceride-glucose index (>9.2877) is an independent predictor of 5-year major cardiovascular events in patients with coronary bifurcation lesions treated with a double-stent strategy.
Answers are grounded in this paper and cite their sources.
May support risk stratification in double-stent bifurcation PCI; leaves open prospective validation and therapeutic implications.
OBJECTIVE: Coronary artery bifurcation lesions (CBLs) represent a complex form of coronary artery disease (CAD) and are associated with an unfavorable long-term prognosis. The triglyceride-glucose index (TyGi) has been shown to provide valuable prognostic information regarding the risk of major cardiovascular events (MACEs) in patients with CAD. This study aimed to determine whether an elevated TyGi could predict MACEs, including target lesion revascularization (TLR), myocardial infarction (MI), and all-cause mortality, over a five-year follow-up period in patients with CBLs undergoing a double-stent strategy. METHOD: This study included 552 patients who underwent a double-stent strategy between January 2010 and December 2020. RESULTS: Receiver operating characteristic analysis identified an optimal TyGi cut-off value of 9.2877. Patients were subsequently divided into a low-TyGi group (Group 1) and a high-TyGi group (Group 2). During the five-year follow-up period, the incidence of MACEs was recorded. Kaplan-Meier analysis demonstrated a higher incidence of MACEs in Group 2 than in Group 1 (P = 0.008). In multivariate Cox regression analysis (CRA), ejection fraction, presence of a complex bifurcation lesion, TyGi, and SYNTAX score (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) were predictors of MACEs (P < 0.05). CONCLUSION: An elevated TyGi may serve as a useful predictor of MACEs in patients with bifurcation lesions undergoing a double-stent strategy.
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Altuntaş et al. (2026) conducted a cohort in Coronary artery bifurcation lesions undergoing a double-stent strategy (n=552). High triglyceride-glucose index (TyGi > 9.2877) vs. Low triglyceride-glucose index (TyGi ≤ 9.2877) was evaluated on Major cardiovascular events (MACEs), including target lesion revascularization (TLR), myocardial infarction (MI), and all-cause mortality (p=0.008). High triglyceride-glucose index (>9.2877) was associated with a higher 5-year incidence of MACEs compared to a low index (P=0.008) in patients undergoing a double-stent strategy.
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