Key result
Bail-out supersaturated oxygen therapy restores distal perfusion in refractory post-PCI no-reflow.
Why the study?
No-reflow is a high-risk complication of PCI associated with larger infarct size, ventricular dysfunction, and mortality, and can be refractory to extensive pharmacologic therapy and thrombectomy.
Does supersaturated oxygen therapy restore distal perfusion in patients with refractory no-reflow following PCI for non-ST-elevation ACS?
Case Report (n=1)
No
Does supersaturated oxygen therapy restore distal perfusion in patients with refractory no-reflow following PCI for non-ST-elevation ACS?
Supersaturated oxygen therapy successfully restored distal perfusion as a bail-out strategy in a case of treatment-resistant no-reflow following PCI for NSTE-ACS.
Answers are grounded in this paper and cite their sources.
May support supersaturated oxygen as bailout in refractory no-reflow; leaves open efficacy pending prospective trials.
No-reflow is high-risk complication of PCI, associated with larger infarct size, ventricular dysfunction, and mortality. We describe a 62-year-old man with a distal RCA lesion who developed refractory no-reflow despite extensive pharmacologic therapy and thrombectomy. Supersaturated oxygen therapy, used as a bail-out strategy, restored distal perfusion and may represent an emerging option for patients with severe, treatment-resistant no-reflow.
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Carvalho et al. (2026) conducted a case report in Refractory no-reflow following PCI for non-ST-elevation ACS in a distal RCA lesion (n=1). Supersaturated oxygen therapy was evaluated on Restoration of distal perfusion. Supersaturated oxygen therapy as a bail-out strategy restored distal perfusion in 1 patient (62-year-old male) with refractory no-reflow after PCI for non-ST-elevation ACS.
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