Additional file 1 of Moderate aortic stenosis identified during intensive care admission for a non-cardiac primary diagnosis and 90-day mortality: a retrospective cohort study using the MIMIC-IV echocardiography database

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Moderate aortic stenosis. Intervention: Moderate aortic stenosis. Primary outcome: 90-day mortality.

Lujun Shao; Cheng Xu; Huiyu Tai; Yue Li

doi:10.6084/m9.figshare.34965075

August 13, 2026Open Access

Additional file 1 of Moderate aortic stenosis identified during intensive care admission for a non-cardiac primary diagnosis and 90-day mortality: a retrospective cohort study using the MIMIC-IV echocardiography database

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Key result

Moderate aortic stenosis is evaluated for 90-day mortality in non-cardiac ICU patients.

or 90

Key Points

To provide supplementary methodological details, statistical models, and sensitivity analyses examining the relationship between moderate aortic stenosis and 90-day mortality in critically ill non-cardiac patients.
Analyzed clinical and imaging data from the retrospective MIMIC-IV echocardiography database.
Employed multivariable regression and propensity-score matching to balance baseline covariates between groups.
Conducted sensitivity analyses, subgroup evaluations, time-stratified hazard ratio calculations, and velocity-gradient cross-classifications.
Presents comprehensive variable definitions and full multivariable risk adjustment models in supplementary tables.
Documents covariate balance before and after propensity-score matching across the clinical cohort.
Reports concordance, subgroup-specific, and time-stratified hazard ratios to assess the robustness of the primary mortality findings.

Study Design

Type

Cohort

Structured PICO

P

Population

Patients admitted to the intensive care unit for a non-cardiac primary diagnosis in the MIMIC-IV echocardiography database, followed for 90 days.

O

Outcome

90-day mortalityhard clinical

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Implication

Robust adjustment strengthens observational data on moderate AS and ICU mortality; leaves open causal effects and should not change practice.

Abstract

Additional file 1: Supplementary methods and Tables S1–S5. Detailed data sources and cohort definition, the full multivariable model (Table S1), covariate balance before and after propensity-score matching (Table S2), the velocity–gradient cross-classification (Table S3), the concordance, sensitivity, subgroup, and time-stratified hazard ratios (Table S4), and definitions of all study variables (Table S5).

Discussion

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Cite This Study

Shao et al. (2026) conducted a cohort in Moderate aortic stenosis. Moderate aortic stenosis was evaluated on 90-day mortality. Moderate aortic stenosis during non-cardiac ICU admission was evaluated for 90-day mortality in supplementary tables S1–S5, though no quantitative results are reported in this file description.

synapsesocial.com/papers/6af46da27bb3da179b850279 https://doi.org/10.6084/m9.figshare.34965075

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Additional file 1 of Moderate aortic stenosis identified during intensive care admission for a non-cardiac primary diagnosis and 90-day mortality: a retrospective cohort study using the MIMIC-IV echocardiography database

Key Points

Study Design

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Additional file 1 of Moderate aortic stenosis identified during intensive care admission for a non-cardiac primary diagnosis and 90-day mortality: a retrospective cohort study using the MIMIC-IV echocardiography database

Key Points

Study Design

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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