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Algorithmic bias in healthcare machine learning (ML) frequently shows up along overlapping social dimensions—like gender, race, and age—leading to layered disadvantages that approaches looking at just one attribute at a time tend to miss. To tackle this, we present a flexible, model-agnostic framework built specifically to uncover, measure, and reduce intersectional bias in healthcare AI systems. The framework brings together five fairness metrics that have low mutual correlation, combining them into a single composite fairness score (denoted as F) that can capture disparities not only within individual groups but also across combinations of sensitive attributes. Using a multi-dimensional grid search, we systematically test various ML models alongside different bias-mitigation strategies, with explicit attention to how well they perform on intersectional subgroups. To help practitioners make informed choices, we map the trade-offs between fairness and accuracy in visual fairness–accuracy landscapes. We test our approach on three real-world tabular healthcare datasets, uncovering how fairness and predictive performance interact across complex subgroup intersections. Our results highlight a key insight: some bias-mitigation techniques boost fairness for single or pairwise attributes but can actually worsen inequities when more dimensions of identity overlap.
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Paiva et al. (2026) studied this question.
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