Analysis of Drug Resistance of Human Klebsiella Pneumoniae and Its Public Health Significance

Klebsiella pneumoniae is an important zoonotic pathogen, and its drug resistance poses a serious threat to public health and clinical treatment. In this study, 30 clinical isolates of human K. pneumoniae were analyzed to evaluate their resistance profiles and public health implications. MICs of 8 antibiotics were determined by broth microdilution and interpreted using CLSI M100 (2024). All strains were 100% susceptible to colistin. Resistance rates were: ceftazidime 53.33%, ceftriaxone 60.00%, ciprofloxacin 53.33%, gentamicin 46.67%, and amikacin 40.00%. According to the criterion of resistance to ≥3 antibiotic classes, 16 strains (53.33%) were classified as multidrug-resistant (MDR), mainly co-resistant to cephalosporins, quinolones, and aminoglycosides. Although the resistance rates to carbapenems (imipenem 33.33% and meropenem 40.00%) were lower than those to cephalosporins, the presence of carbapenem resistance remains concerning. These findings provide preliminary local phenotypic data for clinical antimicrobial resistance surveillance, rather than broad conclusions on public health threats.