The Role of Endocrine Disruptors in the Occurrence of Urogenital Anomalies Among Newborn Males

Objective: This investigation was designed to determine whether there is a correlation between urogenital anomalies (UGAs) and maternal and paternal-related factors in newborn males. Methods: Out of 2410 males, 75 were found to have UGAs, thus representing 3.1% of the recruited male neonates. 54 neonates had undescended testis (UT), accounting for 2.24% of all neonates with UGAs, and 21 neonates had Hypospadias (HS), which represented 0.87% of all neonates with UGAs. A questionnaire was arranged to gather data from mothers of all recruited neonates. Results: Rural regions exhibited a higher prevalence of urogenital anomalies than urban regions. Furthermore, there was a higher prevalence among non-construction workers than among construction workers. With each year of maternal age, the probability of undescended testicles in neonates increased by 0.114, while it decreased by 0.158 when the father's occupation was non-construction (p-values: 0.04 and 0.005, respectively). Conclusion: The study emphasized environmental risks, such as living in rural areas and the father's occupation, and suggested that nutritional factors might offer a protective effect against UGA.