Fruit seed extracts: A class of natural anticancer candidate resources (Review)

The present review aimed to explore the anticancer potential of fruit seeds, focusing on their bioactive components and mechanisms of action to evaluate the application of these natural by-products in cancer intervention.In the present article, fruits are categorized into four major groups, namely berries, stone fruits (drupes), pepo fruits (melons) and aggregate fruits.The review summarizes the active components in seeds of different families and also explains the anticancer mechanisms of polyphenols, terpenoids and other compounds.Fruit seeds from different plant families contain distinct sets of active compounds.These chemical differences lead to varied anticancer potentials.However, the extraction process needs to be standardized and clinical translation research should be accelerated.Contents 1. Introduction 2. Anticancer activities of seeds from different fruit groups 3. Main types of chemical components in fruit seeds 4. Mechanism of anticancer action of fruit seed extract 5. Current challenges and future perspectives 6.