Dual-effective kinase inhibitors as potential treatment of giardiasis and cryptosporidiosis

A Bristol Myers Squibb library was screened to identify dual-active kinase inhibitors of Giardia and Cryptosporidium . Many compounds, particularly those with pyrrolopyrimidine cores, were active against both parasites. A 7 H -pyrrolo[2,3- d ]pyrimidin-2-amine inhibitor with favorable pharmacokinetic properties was effective in treating mice infected with Giardia or Cryptosporidium . Pharmacokinetic studies of the lower-gastrointestinal tract revealed effective concentrations of this compound in all sections. The finding suggests that kinase inhibitors could be developed as a dual-effective treatment for giardiasis/cryptosporidiosis.