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Schizoaffective disorder is a complex psychiatric condition characterized by the concurrent presence of prominent affective symptoms and schizophrenic-type psychotic symptoms. Non-adherence to treatment represents one of the most critical clinical challenges, often leading to recurrent relapses and deterioration of psychosocial functioning. This case report aims to analyze the clinical phenotype, psychodynamic formulation, and holistic management strategies in a case of manic-type schizoaffective disorder (F25.0) comorbid with non-adherence to medical treatment (Z91.1). A 49-year-old female patient was hospitalized with primary complaints of bizarre delusions (believing she was targeted by black magic) and talking to herself starting 15 days prior to admission. Mental status examination revealed elation, labile affect, persecutory and control delusions regarding a spiritual figure (Ida Betara Hyang Guru), and auditory hallucinations of the commenting type. The patient had a history of two previous psychiatric hospitalizations and had unilaterally discontinued her psychotropic medication two years ago. Integrated therapeutic management included adjusting a combination of antipsychotics and mood stabilizers (Trifluoperazine and Valproic Acid), administering long-acting injectable antipsychotics (Fluphenazine decanoate/Sikzonoat), and implementing psychoeducation alongside Family-Focused Therapy (FFT). Clinical evaluation demonstrated significant improvement in affective stability, reduction of psychotic symptoms, and enhanced family engagement in medication monitoring. ABSTRAK Gangguan skizoafektif merupakan kondisi psikiatri kompleks yang ditandai oleh kemunculan simultan gejala afektif utama dan gejala psikotik tipe skizofrenia. Ketidakpatuhan terhadap pengobatan menjadi salah satu tantangan klinis terbesar yang memicu kekambuhan berulang serta penurunan fungsi psikososial pasien. Laporan kasus ini bertujuan untuk menganalisis fenotip klinis, dinamika psikodinamika, serta strategi penatalaksanaan holistik pada kasus gangguan skizoafektif tipe manik (F25.0) berkomorbid dengan ketidakpatuhan terhadap pengobatan (Z91.1). Pasien perempuan berusia 49 tahun dirawat inap dengan keluhan utama waham bizar (merasa terkena serangan ilmu hitam) dan perilaku berbicara sendiri sejak 15 hari sebelum masuk rumah sakit. Pada pemeriksaan status mental ditemukan mood elasi, afek labil, waham curiga, waham kejar, waham kendali oleh figur spiritual (Ida Betara Hyang Guru), serta halusinasi auditorik tipe berkomentar. Pasien memiliki riwayat rawat inap dua kali dan menghentikan pengobatan psikofarmaka secara mandiri sejak dua tahun terakhir. Penatalaksanaan dilakukan secara terintegrasi meliputi penyesuaian kombinasi antipsikotik dan pemantap suasana hati (Trifluoperazine dan Asam Valproat), antipsikotik long-acting injectable (Sikzonoat), serta intervensi psikoedukasi dan Family-Focused Therapy (FFT). Evaluasi klinis menunjukkan perbaikan nyata pada stabilitas afek, reduksi gejala psikotik, dan peningkatan pemahaman keluarga terhadap pengawasan pengobatan.
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Parisudha et al. (2026) studied this question.
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