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Background Children and adolescents with disorders of sex development (DSD) face complex medical and psychosocial challenges, yet data on health-related quality of life (HRQoL) in Thailand remain limited. This study examined HRQoL, depression, and anxiety among Thai youth with DSD and identified factors associated with HRQoL. Methods A cross-sectional study was conducted among 47 patients aged 8-18 years attending a pediatric endocrine clinic in Bangkok (November 2022-May 2023). Participants completed the Thai versions of the PedsQL™ 4.0, CDI, CES-D, and SCARED. Independent t-tests, one-way ANOVA, and Pearson correlation were used. Results The mean age was 13.2 ± 3.2 years. The HRQoL score was high (M = 87.6, SD = 9.9). Anxiety and depression were present in 17.0% and 8.6% of participants, respectively. Higher depression (CES-D: r = −.63, p < .001) and anxiety (SCARED: r = −.41, p < .001) were associated with lower HRQoL. Participants with psychiatric comorbidity had lower HRQoL (mean difference = −14.7, p = .001). HRQoL did not differ by clinical characteristics. Conclusions Psychological factors, rather than medical history, are the strongest correlates of HRQoL, supporting routine mental health screening and integrated care in DSD management.
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Charoenchainow et al. (2026) studied this question.
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