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Abstract 2,2-Bis(hydroxymethyl)propionic acid polyester dendrimers bearing three β-cyclodextrins (β-CD) units (G2[CD]3) and six β-CD units (G3[CD]6) at their periphery were successfully synthesized via Cu(I)-catalyzed click reactions. The formation of inclusion complexes between a hydrophobic imidazoquinoline, a TLR7/8 agonist, and G2[CD]3 or G3[CD]6 in water was confirmed by spectroscopic measurements.
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Fujimoto et al. (2026) studied this question.
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