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A facile convenient method has been developed to construct aryl group on C-3 and C-5 positions of β-anhydroicaritin via Suzuki coupling reaction. The synthesised β-anhydroicaritin derivatives have been charactered by 1HNMR,13NMR and HRMS spectrum. Among them, derivatives 4c and 7g exhibited over 50% growth inhibition against HepG2, whereas 4c, 4g, and 7g showed significant activity against MCF-7, with 7g surpassing 70% inhibition.
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Li et al. (2026) studied this question.
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