Hypertension and Chronic Bronchitis in Adult Men: Impact and Association of Serum LDL-Cholesterol and cfDNA

Q: What are the key findings of this study?

Adult men with hypertension exhibited higher serum LDL-C and cfDNA than healthy controls, with a positive correlation.

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Hypertension and Chronic Bronchitis (n=390). Intervention: Hypertension (and Chronic Bronchitis) vs. Normal healthy adult male controls. Primary outcome: Serum LDL-Cholesterol (mg/dL) and cell-free DNA (ng/mL) levels and their linear correlation in hypertension vs. normal controls (R2 0.80 (LDL-C vs cfDNA correlation in HTN), p=<0.001).

Q: What does this research mean for the field?

Adult men with hypertension exhibit significantly elevated levels of serum LDL-cholesterol and cell-free DNA that are strongly positively correlated with each other, whereas levels remain unaltered in chronic bronchitis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate the impact and association of serum low-density lipoprotein cholesterol and cell-free DNA in adult men with hypertension and chronic bronchitis compared to healthy controls.

Ahmad H. Mufti; Waheeb Alharbi

doi:10.47310/jpms2026151011

November 5, 2026Journal of Pioneering Medical ScienceOpen Access

Hypertension and Chronic Bronchitis in Adult Men: Impact and Association of Serum LDL-Cholesterol and cfDNA

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Key result

Hypertension linked to higher LDL-C and ~44% elevated cfDNA levels in adult men.

R2 0.80 (LDL-C vs cfDNA correlation in HTN)
P<0.001
n=390

Why the study?

LDL-C and cfDNA may be important factors in developing hypertension and chronic bronchitis, but prior reports on their impact in adult men were inconclusive and controversial.

Are serum LDL-cholesterol and cell-free DNA (cfDNA) levels elevated and correlated in adult men with hypertension or chronic bronchitis compared with healthy controls?

Key Points

To evaluate the impact and association of serum low-density lipoprotein cholesterol and cell-free DNA in adult men with hypertension and chronic bronchitis compared to healthy controls.
Enrolled adult male participants aged 51 to 60 years with normal BMI (18.5 to 24.9 kg/m2) across three groups: hypertension (n:130), chronic bronchitis (n:130), and normal healthy controls (n:130).
Measured serum LDL-C and cfDNA using ELISA kits, alongside fasting blood glucose, basal body temperature, hemoglobin, and hepcidin, with comparisons analyzed using unpaired t-tests and linear regression.
Hypertensive patients showed significantly higher levels of LDL-C (103.91±12.98 vs. 95.78±7.76 mg/dL, p<0.001) and cfDNA (158.73±95.60 vs. 110.46±64.31 ng/mL, p<0.001) compared with healthy controls.
A significant positive linear correlation was detected between LDL-C and cfDNA among hypertensive patients (R2 = 0.80, p<0.001).
Chronic bronchitis patients demonstrated no significant differences compared to controls in LDL-C (97.08±8.06 vs. 95.78±7.76 mg/dL, p=0.19) or cfDNA (116.16±63.99 vs. 110.46±64.31 ng/mL, p=0.47).

Study Design

Type

Case-Control (n=390)

Multicenter

Yes

Structured PICO

Are serum LDL-cholesterol and cell-free DNA (cfDNA) levels elevated and correlated in adult men with hypertension or chronic bronchitis compared with healthy controls?

P

Population

390 adult men aged 51-60 years with normal BMI (18.5-24.9 kg/m2) across three groups (130 with hypertension, 130 with chronic bronchitis, and 130 healthy controls) without diabetes or other serious cardiovascular disorders.

E

Exposure

Exposure to hypertension (n=130) or chronic bronchitis (n=130)

C

Comparator

Normal healthy adult male controls (n=130) matched for age range (51-60 years) and normal BMI (18.5-24.9 kg/m2)

O

Outcome

Serum Low Density Lipoprotein Cholesterol (LDL-C, mg/dL) and cell-free deoxyribonucleic acid (cfDNA, ng/mL) levels, and the linear correlation between LDL-C and cfDNAsurrogate

Main Result

Effect estimate: R2 0.80 (LDL-C vs cfDNA correlation in HTN)

Absolute Event Rate: 103.91% vs 95.78%

p-value: p=<0.001

Demonstrates that serum LDL-C and cell-free DNA are significantly elevated and strongly positively correlated in non-obese adult men with hypertension, suggesting an interplay between dyslipidemia, tissue damage, and vascular inflammation, whereas no such association was seen in chronic bronchitis.

Limitations

Study included only adult men aged 51-60 years, precluding evaluation of age-wise variations or gender differences.
Overweight and obese participants (BMI outside 18.5-24.9 kg/m2) and patients with other serious comorbidities (diabetes, stroke, metabolic syndrome) were excluded.
The study was not conducted for age-wise variations and associations as all participants were restricted to 51-60 years.
The study was conducted only in adult men, so it cannot be compared and explained for gender differences.
Overweight and obese participants and patients with serious disorders (other CVDs, diabetes, stroke, metabolic syndrome) were excluded.

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Implication

Hypertension-associated LDL-C and cfDNA elevations are hypothesis-generating; leaves open causal roles or utility for risk stratification in non-obese men.

Abstract

Background: Low Density Lipoprotein Cholesterol (LDL-C) and cell free deoxyribonucleic acid (cfDNA) could be the important factors in the development of hypertension (HTN) and Chronic Bronchitis (CB). In view of inconclusive and controversial reports, we planned to clarify the impact of LDL-C and cfDNA in HTN and CB in adult men. Methods and Results: Adult male patients with HTN (n:130) and CB (n:130) compared with normal healthy adult males (n:130) had same range of age (51-60 years) and body mass index (BMI; 18.5-24.9 kg/m2). LDL-C and cfDNA in CB patients compared with NC did not present any significant variation (p>0.05). HTN vs. NC subjects showed significant increased levels for LDL-C (<0.001) and cfDNA (<0.001) in HTN. Furthermore, LDL-C plotted against cfDNA levels for HTN presented significant positive linear correlation (p<0.001). Plot of LDL-C against cfDNA in CB and association of all other variables with LDL-C and cfDNA in HTN and CB showed non-significant correlations. Conclusions: Present report provides information of the significant impact of increased levels and positive linear correlation of serum LDL-C and cfDNA in adult patients with HTN, possibly involving inflammatory conditions. Increase in BP may increase LDL-C and cfDNA and vice versa via tissue damage and inflammation.

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Cite This Study

Mufti et al. (2026) conducted a case-control in Hypertension and Chronic Bronchitis (n=390). Hypertension (and Chronic Bronchitis) vs. Normal healthy adult male controls was evaluated on Serum LDL-Cholesterol (mg/dL) and cell-free DNA (ng/mL) levels and their linear correlation in hypertension vs. normal controls (R2 0.80 (LDL-C vs cfDNA correlation in HTN), p=<0.001). Adult men with hypertension exhibited higher serum LDL-C and cfDNA than healthy controls, with a positive correlation.

synapsesocial.com/papers/6af5bf07e94012e8747ad9aa https://doi.org/10.47310/jpms2026151011

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Hypertension and Chronic Bronchitis in Adult Men: Impact and Association of Serum LDL-Cholesterol and cfDNA

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Hypertension and Chronic Bronchitis in Adult Men: Impact and Association of Serum LDL-Cholesterol and cfDNA

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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