Key result
Continued exercise improves lipid profiles in dyslipidemia, with greater LDL-C reductions at ≤7.1 METs.
Why the study?
Subject characteristics and differences in exercise parameters may alter the effects of exercise on lipid and lipoprotein levels, motivating an exploration of the ideal exercise program for middle-aged East Asian adults with dyslipidemia.
Does continued regular exercise improve serum lipid and lipoprotein levels (HDL-C, LDL-C, TC, and TG) in middle-aged East Asian adults with dyslipidemia, and how do exercise program variables (FITT) influence these effects?
Meta-Analysis (n=501)
Randomized controlled trials
Yes
Does continued regular exercise improve serum lipid and lipoprotein levels (HDL-C, LDL-C, TC, and TG) in middle-aged East Asian adults with dyslipidemia, and how do exercise program variables (FITT) influence these effects?
In middle-aged East Asian adults with dyslipidemia, continued low- to moderate-intensity exercise (<=7.1 METs, and <=5.8 METs for women) for at least 8 weeks is effective for reducing LDL-C levels.
Answers are grounded in this paper and cite their sources.
Supports low-intensity exercise for LDL-C reduction in East Asian women with dyslipidemia; extends RCT meta-analyses by identifying intensity and sex moderators.
Background:Exercise therapy is one way to improve non-communicable diseases, but subjects’ characteristics and differences in the exercise performed may alter the effects of exercise on lipid and lipoprotein levels in adults with dyslipidemia. Aim:The current systematic review and meta-analysis explored the ideal exercise program (frequency, intensity, type, and time [FITT]) for improving dyslipidemia in middle-aged East Asian adults. Subjects and methods:Inclusion criteria were interventions involving only continued exercise. The mean differences (MD) in serum lipid and lipoprotein levels were calculated and pooled as overall effects. A meta-regression analysis was performed to evaluate the relationship between FITT variables and the MDs. Results:Thirteen studies (501 subjects) were analyzed. The pooled MDs in serum lipid and lipoprotein levels improved significantly, but low-density lipoprotein cholesterol (LDL-C) contained significant heterogeneity (I2=54.7%). A meta-regression analysis revealed that a decrease in exercise intensity (metabolic equivalents [METs]) and female subjects (%) were significantly associated with a decrease in the LDL-C, and the heterogeneity was improved (I2=12.7%). Conclusion:In East Asian adults with dyslipidemia, low to moderate-intensity exercise might be effective at improving LDL-C. J. Med. Invest. 73 : 365-372, August, 2026
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Igarashi et al. (2026) conducted a meta-analysis in Dyslipidemia (n=501). Continued exercise program vs. No exercise / usual lifestyle was evaluated on Change in serum lipid and lipoprotein levels (specifically low-density lipoprotein cholesterol [LDL-C]). Continued exercise improved lipid profiles in East Asians with dyslipidemia, with exercise intensity and female sex associated with greater LDL-C reductions.
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