Faktor Yang Berhubungan Dengan Kejadian Acute Coronary Syndrome

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Acute Coronary Syndrome (STEMI and NSTEMI) (n=153). Intervention: Hyperlipidemia (Total Cholesterol >200 mg/dL and HDL =40 mg/dL). Primary outcome: Acute Coronary Syndrome subtype (NSTEMI vs STEMI) associated with Total Cholesterol hyperlipidemia (p=0.039).

Q: What does this research mean for the field?

Hyperlipidemia (specifically total cholesterol and HDL levels) is significantly associated with acute coronary syndrome, whereas hypertension and diabetes mellitus show no significant association. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Muhammad Sahlan Zamaa; Dewi Purnama Windasari; La Ode Nuh Salam; Sitti Nurhadijah; Sri Wahyunita Aswar

doi:10.51171/jms.v16i4.755

November 8, 2026Jurnal MitrasehatOpen Access

Faktor Yang Berhubungan Dengan Kejadian Acute Coronary Syndrome

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Key result

Hyperlipidemia defined by total cholesterol and HDL is significantly associated with acute coronary syndrome.

P=0.039
n=153

Why the study?

Acute coronary syndrome is an ischemic heart disease that ranked among the top 10 causes of mortality in 2019, prompting an investigation into factors associated with its occurrence.

Key Points

To identify clinical factors associated with the incidence of acute coronary syndrome among patients admitted to an intensive cardiovascular care unit.
Conducted an analytic survey with a cross-sectional design involving 153 patients diagnosed with acute coronary syndrome at Ruang CVCU RSUP Dr. Wahidin Sudirohusodo Makassar.
Selected participants using purposive sampling and collected secondary clinical data from hospital records.
Analyzed associations between potential risk factors and acute coronary syndrome incidence using the Fisher Exact Test.
Hyperlipidemia, specifically total cholesterol and high-density lipoprotein (HDL) levels, demonstrated a significant association with the occurrence of acute coronary syndrome.

Study Design

Type

Cross-Sectional (n=153)

Multicenter

No

Structured PICO

P

Population

153 hospitalized adults (24.8% female, aged 34 to >76 years) diagnosed with STEMI or NSTEMI in a single Indonesian cardiovascular care unit during 2021.

O

Outcome

Type of Acute Coronary Syndrome presentation (NSTEMI vs. STEMI) and its association with hyperlipidemia (total cholesterol, HDL, LDL, triglycerides), hypertension, and diabetes mellitushard clinical

Main Result

Absolute Event Rate: 81% vs 92.6%

p-value: p=0.039

Limitations

Retrospective cross-sectional design using secondary medical record data
Single-center study with purposive sampling
Lipid levels may have been confounded by dietary habits, timing of blood collection after infarction, and in-hospital statin administration

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Implication

In this single-center Indonesian cross-sectional study of 153 ACS patients, total cholesterol and HDL abnormalities were significantly associated with ACS presentation type (NSTEMI vs. STEMI), whereas LDL, triglycerides, hypertension, and diabetes mellitus were not.

Abstract

Latar belakang: Acute Coronary Syndrome (ACS) merupakan salah satu penyakit jantung iskemik. Penyakit jantung iskemik termasuk 10 penyebab kematian di tahun 2019 dan menyumbang 55% dari 55,4 juta kematian di seluruh dunia. Tujuan: Untuk mengetahui faktor yang berhubungan dengan kejadian ACS. Metode: Penelitian ini menggunakan desain survei analitik dengan pendekatan cross-sectional. Populasi penelitian ini yaitu semua pasien yang dirawat dengan diagnosis ACS di Ruang CVCU RSUP Dr. Wahidin Sudirohusodo Makassar, dengan besar sampel sebanyak 153 pasien yang dipilih menggunakan purposive sampling. Pengumpulan data menggunakan data sekunder dan dianalisis menggunakan uji Fisher Exact Test. Hasil: Ada hubungan antara hiperlipidemia (kolesterol total dan HDL) dengan kejadian ACS, tidak ada hubungan antara hipertensi dan diabetes melitus dengan kejadian ACS. Kesimpulan: Kesimpulan dari penelitian ini yaitu ada hubungan antara hiperlipidemia dengan kejadian ACS. Disarankan kepada pasien ACS untuk melakukan pemeriksaan kesehatan rutin guna mencegah komplikasi lebih lanjut.

Discussion

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Cite This Study

Zamaa et al. (2026) conducted a cross-sectional in Acute Coronary Syndrome (STEMI and NSTEMI) (n=153). Hyperlipidemia (Total Cholesterol >200 mg/dL and HDL <40 mg/dL) vs. Non-hyperlipidemia (Total Cholesterol <=200 mg/dL and HDL >=40 mg/dL) was evaluated on Acute Coronary Syndrome subtype (NSTEMI vs STEMI) associated with Total Cholesterol hyperlipidemia (p=0.039). Hyperlipidemia defined by total cholesterol and HDL was associated with acute coronary syndrome, whereas hypertension and diabetes were not.

synapsesocial.com/papers/6af5cd26a40bbe8669e89c25 https://doi.org/10.51171/jms.v16i4.755

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Faktor Yang Berhubungan Dengan Kejadian Acute Coronary Syndrome

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Faktor Yang Berhubungan Dengan Kejadian Acute Coronary Syndrome

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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