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The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Trisodium Ethylenediamine Disuccinate and Tetrasodium Iminodisuccinate as used in cosmetics. These ingredients are reported to function in cosmetics as chelating agents. The Panel reviewed the available data to determine the safety of these ingredients, and concluded that Trisodium Ethylenediamine Disuccinate and Tetrasodium Iminodisuccinate are safe in cosmetics in the present practices of use and concentration as described in the safety assessment.
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Ferguson et al. (2026) studied this question.
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