Current Approaches to the Diagnosis and Treatment of Chronic Pancreatitis

Chronic pancreatitis is a progressive inflammatory disease of the pancreas that leads to irreversible replacement of normal tissue with scar tissue, persistent pain, exocrine and endocrine insufficiency, impaired nutrition and reduced quality of life. Aim: to summarize current approaches to the diagnosis and treatment of chronic pancreatitis. An analytical review of the scientific literature was performed, with data systematized by causes, diagnosis, and conservative, endoscopic and surgical treatment. Risk factors and mechanisms of the disease, the role of imaging and assessment of fibrosis, approaches to pain management, enzyme replacement therapy and correction of nutritional disorders, and indications for endoscopic and surgical interventions are described. Effective treatment of chronic pancreatitis requires early detection, elimination of causal factors, comprehensive therapy of pain and gland insufficiency, and multidisciplinary cooperation.