Comparative Evaluation of Bone Regeneration With L‐PRF, Amniotic Membrane, Simvastatin Using CBCT After Endodontic Surgery: Randomized Clinical Trial

The present study evaluates and compares the effectiveness of Leucocyte–platelet rich fibrin (L‐PRF), Simvastatin (SIM) and amniotic membrane (AM) in bone regeneration of periapical defects. A total of 42 patients fulfilling all the inclusion criteria were enrolled for the study and randomly divided into three groups ( n = 14) by allocation concealment method. Group I (L‐PRF = 14), Group II (SIM = 14), Group III (AM = 14). A total of 36 patients (12 in each group) were statistically analysed for results after excluding the data lost to follow‐up in all three groups. Intragroup analysis of CBCT‐Periapical Index (PAI) scores at 6th and 12th month revealed considerable change in the SIM ( p = 0.053 and 0.231, respectively) compared to L‐PRF group ( p = 0.135 and 0.406, respectively) and AM (0.531 and 0.494, respectively). When used as a bone graft material, simvastatin showed numerically higher but not statistically significant results ( p > 0.05). Trial Registration: The study was registered to the Clinical Trials Registry‐India (CTRI), with a registration number CTRI/2022/08/044782, before the commencement of the study