Digital connectivity in plateletpheresis collections improves productivity and workflow efficiency without compromising donor safety

Background and Objectives Blood banks face pressure to meet the growing demand for platelet components while improving operational efficiency and maintaining donor and patient safety. This study describes a data‐driven strategy using connectivity tools to reduce data transfer errors, optimize workflow, and safely implement high‐yield platelet collections. Materials and Methods This retrospective observational study analyzed plateletpheresis procedures performed with Trima Accel™ Automated Blood Collection System between January 2022 and November 2025 at Fundação Pró‐Sangue, São Paulo. In November 2022, the Terumo Operational Medical Equipment Software (TOMEs™) middleware was implemented to establish a bidirectional interface between apheresis devices and the blood bank information system. Data‐driven simulations identified donors eligible for high‐yield collections, enabling the introduction of triple‐dose plateletpheresis in October 2024. Variables included donor data discrepancies, adverse events, procedure duration, platelet yield, predicted post‐procedure platelet counts, anticoagulant use, inter‐donation intervals, and workflow efficiency. Outcomes before and after implementation were compared. Results Integration of the bidirectional interface reduced donor data discrepancies from 47% to 3%, and decreased manual interactions by 30%, improving data reliability and operational efficiency. Simulations showed that 30% of donors met Brazilian regulatory criteria for triple‐dose plateletpheresis. After implementation, plateletpheresis productivity increased 16%. Adverse event rates remained low and comparable before and after implementation (8.2% vs. 7.9%). Predicted post‐procedure platelet counts in triple donors remained within the device safety threshold recommended by Brazilian policies. Conclusion Digital integration and data‐driven decision‐making enable the safe implementation of triple‐dose plateletpheresis, improving productivity without compromising donor safety. This approach may serve as a practical model for blood centers, particularly in resource‐limited settings.