Key result
Hyperglycemia linked to ~2.3-fold higher risk of no-reflow during PCI for STEMI.
Why the study?
The no-reflow phenomenon (NRP) is a complication associated with in-hospital mortality in STEMI patients undergoing PCI, and hyperglycemia can be observed regardless of diabetes mellitus. This study aimed to determine the association between NRP and hyperglycemia.
Does hyperglycemia (glucose index > 140 mg/dL) increase the risk of the no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention?
Observational (n=159)
No
Does hyperglycemia (glucose index > 140 mg/dL) increase the risk of the no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention?
A glucose index > 140 mg/dL at hospitalization is an independent predictor associated with a 2.27-fold increased odds of developing the no-reflow phenomenon during PCI in STEMI patients.
Answers are grounded in this paper and cite their sources.
May heighten no-reflow vigilance in hyperglycemic STEMI PCI; leaves open whether glucose control reduces incidence.
Introduction: The no-reflow phenomenon (NRP) is a complication associated with in-hospital mortality in patients undergoing percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI).Hyperglycemia in these patients can be observed regardless of diabetes mellitus.Objective: Determine the association between NRP and hyperglycemia.Methods: All patients with STEMI who underwent PCI at the ISSEMyM Medical Center from March 1st, 2019, to March 1st, 2020, were identified, and of these those who presented NRP.A cutoff value of glucose index > 140 was used for the development of the non-reflux phenomenon.The data evaluated with a normal curve, averages, and standard deviation were obtained, and with an asymmetric curve, median, and 25th and 75th percentile.The association of variables was applied with Pearson's χ 2 test and OR values according to the statistical significance obtained, taking P as a criterion < 0.05.Results: NRP was present in 32 cases (20.1%), and glucose index value ≥ 140 mg/dL was found, with statistical significance OR 2.27 (95% confidence interval: 1.01, 5.1).Conclusion: A glucose index > 140 mg/dL during a STEMI is a common finding and an adverse prognostic marker that increases the risk of NRP.
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Varela et al. (2024) conducted an observational in Acute ST-segment elevation myocardial infarction (STEMI) (n=159). Hyperglycemia (glucose index > 140 mg/dL) vs. Glucose index < 140 mg/dL was evaluated on No-reflow phenomenon (NRP) during coronary angiography (OR 2.27, 95% CI 1.01, 5.1, p=0.044). Hyperglycemia was associated with an increased risk of the no-reflow phenomenon in STEMI patients undergoing PCI.
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