Key result
Hypertension linked to at least ~10% higher risk of post-stroke readmission alongside AF and diabetes.
Why the study?
Whether the risk factors for hospital readmission in stroke survivors differ from those contributing to stroke occurrence had not been established. This study sought to identify modifiable risk factors for 30-day and 1-year readmission after stroke and model their relationships with readmission.
What are the modifiable risk factors associated with 30-day and 1-year hospital readmission in stroke survivors?
Systematic Review
What are the modifiable risk factors associated with 30-day and 1-year hospital readmission in stroke survivors?
This umbrella review demonstrates that hypertension is the most consistent modifiable risk factor for 30-day and 1-year post-stroke readmission, highlighting the need for targeted post-discharge secondary prevention and adherence support.
Answers are grounded in this paper and cite their sources.
Target hypertension, AF, diabetes, and adherence for post-stroke secondary prevention; extends meta-analytic evidence on modifiable readmission risks.
Introduction: It has not yet been established whether the risk factors for readmissions of stroke survivors differ from those that contribute to the occurrence of this medical condition. This umbrella review aimed to (1) identify modifiable risk factors for 30-day and 1-year readmission after stroke and (2) develop an evidence-informed illustrative model describing their relationships with readmission. Methods: This umbrella review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. A systematic search of PubMed, Web of Science, Cochrane Library, CINAHL, and Scopus was conducted for studies published up to June 2024. Two reviewers independently screened titles, abstracts, and full texts for eligibility and extracted the relevant data using a standardized data extraction form. Any disagreements were resolved through discussion until consensus was reached. Results: Thirty-one systematic reviews and meta-analyses were included. Hypertension (30-day OR=1.10–2.14; 1-year OR=1.18–2.60), atrial fibrillation (30-day OR=1.26–2.13; 1-year OR=0.57–2.40), diabetes mellitus (30-day OR=1.15–1.40; 1-year OR=0.91–1.40), and treatment non-adherence were the main modifiable risk factors associated with post-stroke readmission. An evidence-informed illustrative model was developed to illustrate the interrelationships among these factors and their contribution to readmission risk. Conclusion: Addressing modifiable cardiovascular risk factors and improving treatment adherence are essential to reducing hospital readmissions after stroke. The developed evidence-informed illustrative model highlights the interrelationships among hypertension, atrial fibrillation, diabetes mellitus, treatment adherence, and post-discharge support, providing a framework for targeted interventions to reduce readmission.
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Rajabpour et al. (2026) conducted a systematic review in Stroke survivors. Modifiable cardiovascular and lifestyle risk factors (hypertension, atrial fibrillation, diabetes mellitus, treatment non-adherence) vs. Absence of modifiable risk factors or treatment adherence was evaluated on Hospital readmission within 30 days and 1 year after stroke discharge (OR 1.10-2.14 (30-day HTN); OR 1.18-2.60 (1-year HTN)). Hypertension, atrial fibrillation, diabetes mellitus, and treatment non-adherence were the main modifiable risk factors for post-stroke readmission.
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