Key result
Beta thalassemia major linked to ~/dL lower total cholesterol alongside reduced LDL and HDL.
Why the study?
The serum lipid profile and its correlation with age and gender in beta thalassemia major patients needed to be assessed.
Does beta thalassemia major alter serum lipid profile parameters compared to healthy controls in patients in Karachi?
Cross-Sectional (n=140)
Yes
Does beta thalassemia major alter serum lipid profile parameters compared to healthy controls in patients in Karachi?
Patients with beta thalassemia major exhibit lower total, LDL, and HDL cholesterol alongside elevated triglycerides and severe iron overload, indicating that standard TC/HDL ratios may not reliably assess coronary risk in this population.
Answers are grounded in this paper and cite their sources.
Lower lipids in beta thalassemia major may not indicate reduced coronary risk; leaves open whether standard ratios apply in this population.
Objective: The aim of this study was to assess the lipid profile in beta thalassemia major patients and observeits correlation with age and gender.Methods: In this cross sectional study, conducted during 2013, 70 βTM patients ( 38 males and 32 females)with mean age 19.92 who were undergoing periodic blood transfusions and desferrioxime as chelating agentwere recruited. 70 controls of matched age and gender were also included in the study. Lipid profile was done byenzymatic colorimetric method on Micro lab 300 (Merck & Co Germany) and statistical comparison was done byusing student’s t test on SPSS: 17Results: βTM patients showed significantly lowered blood cholesterol (105.5 ±19.2 mg/dl), LDL (44.23±19.4 mg/dl) and HDL( 33±4.9 mg/dl) in comparison with controls (P value> 0.001) while TAG was level found to be increased(140.2±27 mg/dl) in comparison to normal healthy controls.Conclusion: The mechanisms that may account for these findings are increased erythropoiesis and cholesterolconsumption along with iron overload and oxidative stress in βTM patients. Awareness of these findings is helpfulto avoid unnecessary evaluation and clinical consequences of impaired lipid profile in patients with β thalassemiamajorKeywords: Beta thalassemia major (βTM), Lipid profile.
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Memon et al. (2015) conducted a cross-sectional in Beta thalassemia major (n=140). Beta thalassemia major vs. Age- and gender-matched normal healthy controls was evaluated on Serum total cholesterol (mg/dL) (p=<0.05). Beta thalassemia major patients had lower total cholesterol, LDL, and HDL compared to controls.
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