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DNA storage has significant advantages if compared with existing electronic storage systems, usually concentrated in data centers, which form digital cloud infrastructure. These are: longevity, format used by nature, high capacity per volume and small CO2 footprint. Information which is stored and later retrieved from DNA storage systems can be corrupted by insertions, deletions and substitutions (INDELS). Oxford nanopore sequencing is probably the closest to making DNA storage a mass product. On the other hand, different decoding systems based on noise-guessing paradigm also possess advantages when compared with classical error control coding, which has been demonstrated for wide variety of communications channels. Therefore, in this manuscript a proof of concept is given for a DNA storage system with a decoder inspired by the noise-guessing paradigm approach. It is given using a simple model for INDELS obtained from real measured data.
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Hudač et al. (2026) studied this question.
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