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Background: Type 2 diabetes mellitus (T2DM) is associated with cardiometabolic dysfunction and progressive impairment of skeletal muscle health. Sodium–glucose cotransporter 2 inhibitors (SGLT2I) improve cardiovascular and renal outcomes, but their effects on amino acid metabolism, skeletal muscle composition, and physical function remain unclear. β-aminoisobutyric acid (BAIBA), a muscle-related amino acid, may link metabolic regulation with muscle health.
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Yano et al. (2026) studied this question.
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