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Background: Home-based peritoneal dialysis (PD) offers autonomy and flexibility but may involve multidimensional patient-reported burden. Aim: To synthesize evidence on psychological, symptom-related, social, socioeconomic, and practical burden among adults receiving home-based PD. Methodology: Searches were conducted from December 2025 to April 2026 using PubMed and targeted nephrology/nursing sources and updated on 9 September 2026 using CINAHL Plus with Full Text and APA PsycINFO. Primary studies reporting patient perspectives or outcomes relevant to PD or home dialysis were included. PRISMA 2020 guided reporting. Methodological appraisal used the Appraisal Tool for Cross-Sectional Studies (AXIS), the Critical Appraisal Skills Programme (CASP) Qualitative Studies Checklist, the Newcastle–Ottawa Scale (NOS), and the Cochrane Risk of Bias 2 (RoB 2) tool, according to study design. Results: Thirteen studies were included: six cross-sectional, two prospective cohort, four qualitative, and one randomized controlled trial. Findings identified psychological distress, symptom burden, coping and adaptation challenges, and social, socioeconomic, relational, and practical demands. Quality of life was associated with individual, social, socioeconomic, and treatment-related factors. Broader dialysis evidence was treated as contextual when PD-specific findings could not be distinguished. Conclusion: Home-based PD may involve interacting multidimensional burdens. Comprehensive, patient-centred care and further PD-specific research are needed. These burdens may also be clinically relevant to medication self-management and individualized pharmacological care.
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Glyky et al. (2026) studied this question.
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