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Background: People with multiple sclerosis (MS) face disruption to their sense of purpose, meaning, and identity, in addition to physical and psychological symptoms. Nurse-led psychosocial interventions have reduced distress and improved quality of life in other chronic illnesses but are rarely designed to address these outcomes in MS. Methods: This narrative review examined nurse-led psychosocial and psychotherapeutic interventions reported in chronic illness populations (2016-2025), focusing on outcomes related to well-being, coping, and meaning-making, to inform implications for MS care. Results: Cognitive behavioral therapy, life review, approaches informed by logotherapy, and structured education have reduced distress, improved coping, and fostered empowerment across chronic conditions. However, methodological challenges, cultural variability, and limited nurse training present barriers. Conclusions: Nurse-led psychosocial interventions have demonstrated benefits across diverse patient populations and have the potential to help people with MS rebuild purpose, identity, and confidence in daily life.
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Lisa Kelly (2026) studied this question.
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