Improving the Diagnosis of Patients With Nasopharyngeal Angiofibroma Through the Detection of Gstm1 Gene Polymorphism

In this thesis, the role of GSTM1 gene polymorphism in improving the diagnosis of patients with nasopharyngeal angiofibroma is investigated. Particular attention is paid to the genetic mechanisms associated with cellular detoxification and oxidative stress. Nasopharyngeal angiofibroma is a rare, benign but locally aggressive vascular tumor that predominantly affects adolescent males. Early diagnosis and comprehensive assessment of this disease are essential for preventing complications and selecting appropriate treatment strategies. The study focuses on identifying the GSTM1 null genotype using polymerase chain reaction (PCR) and evaluating its possible association with the development of nasopharyngeal angiofibroma. The integration of molecular genetic analysis with clinical, endoscopic, and radiological examination may provide additional information about individual genetic susceptibility and contribute to improving diagnostic approaches. The investigation may also expand current knowledge of the molecular and genetic factors involved in the pathogenesis of nasopharyngeal angiofibroma.