ICU Liberation Bundles: Practical Bedside Methods to Reduce Pain, Over- sedation, and Delirium: An Update

Critically ill patients are exposed to multiple interrelated and potentially modifiable insults, including pain, excessive sedation, delirium, immobility, and sleep disruption. These complications may prolong mechanical ventilation and intensive care unit (ICU) stay andadversely affect neurological, functional, and cognitive recovery. The ICU Liberation Bundle, commonly represented by the ABCDEF bundle, provides an integrated framework for addressing these challenges. This update reviews practical bedside strategies forimplementing ICU Liberation, focusing on pain management, sedation, delirium prevention, early mobilisation, sleep promotion, and family engagement. Systematic pain assessment using validated tools such as the Critical-Care Pain Observation Tool (CPOT) and Behavioral Pain Scale (BPS) should guide analgesia, with the principle of analgesia before sedation. We must target sedation to the lightest effective level, with explicit daily targets and appropriate spontaneous awakening and breathing trials. Delirium should be assessed systematically using validated instruments, while prevention should emphasise multicomponent non-pharmacological interventions, including orientation, sensory aids, sleep promotion, adequate pain control, early mobilisation, and family participation. Routine antipsychotic therapy lacks strong evidence for improving major clinical outcomes. Early progressive mobilisationshould be considered even in mechanically ventilated patients. Sleep-promoting environmental measures remain fundamental, while melatonin may be considered as an adjunct. Family engagement should be incorporated as an active component of recovery. ICU Liberation represents a shift from routine sedation and immobility toward patient-centred care. Reliable interdisciplinary implementation of simple interventions remains central to its success.