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Gangrene of the lower limb is a serious complication commonly associated with Diabetes Mellitus, arising due to ischemia, infection, and neuropathy, often leading to limb loss if not managed effectively. In Ayurveda, a condition comparable to gangrene is described as Vrana Kotha, considered an advanced stage of Duṣṭa Vraṇa predominantly involving vitiation of Pitta doṣa and characterized by progressive tissue necrosis. This case report presents a 65-year-old male with a five-year history of Diabetes Mellitus who developed multiple non-healing ulcers over the right foot for a duration of two months. The condition began after exposure to rainwater, initially presenting with edema and abscess formation, which later progressed to ulceration and dry gangrene with necrotic tissue and clear demarcation. The patient had poor glycemic control and showed minimal response to conventional antibiotic therapy. Management was carried out based on Ayurvedic principles of Prameha Chikitsa and Duṣṭa Vraṇa Chikitsa.
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V. et al. (2026) studied this question.
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