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Absrtact: Present study focusing on the comparative evaluation of analytical methods and pharmacopoeial standards across the Indian Pharmacopoeia (IP) editions 2014, 2018, 2022, and 2026, the present study investigates these editions. The Indian Pharmacopoeia provides official standards for ensuring the identity, purity, strength, and quality of pharmaceutical substances and dosage forms. An assessment of the evolution of pharmaceutical analytical methods, monographs, general chapters, impurity testing, and quality-control procedures across successive editions was undertaken. A comparative review was carried out using official Indian Pharmacopoeia publications, Indian Pharmacopoeia Commission documents, and relevant WHO and ICH guidelines. The review highlights the transition from conventional analytical techniques, such as titration and chemical identification tests, towards advanced instrumental methods, including High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), UV-Visible Spectrophotometry, and Infrared Spectroscopy. It also emphasizes improvements in dissolution testing, related-substance analysis, impurity profiling, and international harmonization. The evolution of pharmacopoeial standards was illustrated by the study's focus on analytical accuracy, specificity, reliability, and pharmaceutical quality assurance.
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Kawale et al. (2026) studied this question.
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