A Case of Myoepithelioma Mimicking Metastasis on PSMA PET/CT: A Rare Pitfall Evaluated with MRI

Myoepithelioma is a rare neoplasm that is usually benign and is most often described in adults. We describe an incidental focus of increased PSMA uptake in the region of the distal phalanx of the great toe in a patient undergoing PSMA PET/CT for initial staging of prostate cancer. While the intense tracer accumulation was initially suspicious for an atypical solitary metastasis, subsequent MRI revealed a well-circumscribed soft tissue lesion. The patient underwent surgical excision, and the diagnosis of myoepithelioma was confirmed. This case highlights that myoepithelioma may represent a rare pitfall in PSMA PET/CT interpretation.