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Natural products play an important role in antischistosomal drug discovery. In this respect, we identified two derivatives of the quinazolinone indole alkaloid asperlicin C with respective LogD7.4 values of 2.8 and 4.6, in vitro human liver microsomal intrinsic clearance (CLint) values of 16.3 and 32.0 μL/min/mg/protein, Schistosoma mansoniin vitro IC50 values of 1.6 and 1.8 μM, and selectivity indices of 21 and 22. These quinazolinone indoles appear to have quite specific activity against schistosomes.
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Kaushik et al. (2026) studied this question.
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