A Multidimensional Framework to Combat HPV Vaccine Misinformation in the Digital Age: Implications for Cervical Cancer Prevention

Human papillomavirus (HPV) vaccination is a cornerstone of cervical cancer prevention, yet its uptake remains constrained by misinformation and myths amplified through social media worldwide. Combating this digital infodemic requires an integrated public health response that unites behavioral science, artificial intelligence (AI), and evidence-based communication. This opinion article proposes a multidimensional framework to strengthen HPV vaccine confidence by: (1) employing prebunking strategies grounded in psychological inoculation theory to build cognitive resistance to misinformation; (2) applying infodemiological modeling for real-time monitoring, predictive analysis, and rapid response; (3) leveraging algorithmic governance to prioritize credible, provaccine content; (4) utilizing AI-driven tools to identify and flag misinformation; and (5) transforming social media into a public health ally. Collectively, these ethically governed, complementary approaches can transform social media from a conduit of misinformation into a powerful catalyst for HPV vaccine confidence and acceptance across the globe.