Association between vitamin D and lipid profiles in a large Chinese cohort of middle-aged to elderly Chinese men and women: the evidence from China precision nutrition and health- KAP real world study (CPNAS)

Background and aims Evidence regarding the association between vitamin D (VD) and dyslipidemia is sparse and inconsistent across studies. Therefore, we sought to examine the association between VD levels and dyslipidemia in a large rural middle-aged and elderly population queue in Rongcheng City, Shandong Province, China. Methods The study sample consisted of 43,375 participants who had complete data records. VD levels were obtained through blood testing. Dyslipidemia was defined as meeting any of the following criteria: 1) Triglycerides (TG) ≥ 1.7mmol/L; 2) Total cholesterol (TCHO) ≥ 5.2mmol/L; 3) Low density lipoprotein cholesterol (LDL-C) ≥ 3.4mmol/L; 4) A previous diagnosis of hyperlipidemia; 5) current use of lipid-lowering medication. Participants who met any of the above five criteria were defined as having dyslipidemia. Results The prevalence of dyslipidemia was 75.1%. On the whole, VD status was found to be negatively association with the presence of dyslipidemia ( OR : 0.94; 95% CI : 0.92, 0.97). Stratified analyses revealed that the inverse association between VD and dyslipidemia remained consistent across all subgroups (all P- interaction > 0.05). Conclusions VD showed negatively correlated with dyslipidemia in the general population.