Key result
NyokAssist enables LV unloading and successful VA-ECMO weaning by day 5 without complications.
Why the study?
Increased LV afterload and distension during VA-ECMO may impede myocardial perfusion in AMI, and the clinical use of the self-expanding NyokAssist percutaneous ventricular assist device for LV unloading during VA-ECMO had not been reported.
Case Report (n=1)
No
Answers are grounded in this paper and cite their sources.
This first-in-human case report demonstrates the technical feasibility and safety of a novel self-expanding percutaneous ventricular assist device (NyokAssist) for active left ventricular unloading during VA-ECMO support in AMI-related cardiogenic shock.
Increased left ventricular (LV) afterload and distension during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support may impede myocardial perfusion in acute myocardial infarction (AMI). Active LV unloading has been associated with improved outcomes. We report the first clinical use of a self-expanding percutaneous ventricular assist device (NyokAssist; magAssist, Suzhou, China) for LV unloading during VA-ECMO in a 56 year old man with AMI-related cardiogenic shock (CS). Successful coronary angiography and percutaneous coronary intervention (PCI) of the culprit left circumflex (LCx) lesion were performed with NyokAssist + VA-ECMO support. The patient was successfully weaned from VA-ECMO on post-procedure day 5 and remained on NyokAssist support alone for an additional 7 days before being transferred on VA-ECMO to a heart transplant center for consideration of advanced heart failure therapies due to limited myocardial recovery. No device-related complications were observed. This case demonstrates the technical feasibility of early implementation of a combined VA-ECMO and NyokAssist support strategy, enabling LV unloading, temporary hemodynamic stabilization, end-organ improvement, and VA-ECMO decannulation in a patient with AMI-related CS. As this report describes a single-patient experience, further clinical studies are warranted to define the safety, efficacy, and potential role of the use of NyokAssist in combination with VA-ECMO in the management of AMI-related CS.
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Cai et al. (2026) conducted a case report in Acute myocardial infarction-related cardiogenic shock (n=1). Self-expanding percutaneous ventricular assist device (NyokAssist) combined with venoarterial extracorporeal membrane oxygenation (VA-ECMO) was evaluated on Technical feasibility, LV unloading, hemodynamic stabilization, and VA-ECMO decannulation. Combined NyokAssist and VA-ECMO enabled LV unloading and VA-ECMO weaning on day 5, followed by 7 days of standalone support with 0 device-related complications.
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