Key result
Outpatient cardiac rehabilitation linked to ~77% lower post-AMI major cardiovascular events risk.
Why the study?
Does outpatient cardiac rehabilitation reduce major adverse cardiovascular events in acute myocardial infarction survivors after emergency percutaneous coronary intervention, and does its effectiveness vary by myocardial injury severity (peak CPK)?
Cohort (n=535)
Does outpatient cardiac rehabilitation reduce major adverse cardiovascular events in acute myocardial infarction survivors after emergency percutaneous coronary intervention, and does its effectiveness vary by myocardial injury severity (peak CPK)?
Outpatient cardiac rehabilitation after emergency PCI for acute myocardial infarction is associated with a significant reduction in MACE, particularly among patients with greater myocardial injury (peak CPK ≥2000 U/L).
Answers are grounded in this paper and cite their sources.
May support targeted cardiac rehabilitation post-AMI with large infarcts; leaves open randomized confirmation of MACE reduction.
Cardiac rehabilitation (CR) is recommended after acute myocardial infarction (AMI), but whether its benefit differs by infarct size remains uncertain. We examined whether the effectiveness of CR varies according to peak creatine phosphokinase (CPK), a surrogate marker of myocardial injury. We retrospectively analyzed 535 AMI survivors who underwent emergency percutaneous coronary intervention between January 2015 and November 2025. Patients were divided into CR and non‑CR groups. The primary endpoint was major adverse cardiovascular events (MACE), defined as all‑cause death, recurrent myocardial infarction, or heart failure hospitalization. Patients were stratified by peak CPK (<2000 vs. ≥2000 U/L), and Kaplan-Meier and Cox analyses were performed. Among 535 patients, 165 (31%) participated in CR. CR was associated with lower MACE incidence in the overall cohort (hazard ratio [HR] 0.23, 95% confidence interval [CI] 0.14-0.81, p = 0.01). In the high‑CPK subgroup, CR significantly reduced MACE (HR 0.21, 95% CI 0.04-0.96, p = 0.04), whereas the low‑CPK subgroup showed only nonsignificant trend. Similar findings were observed in patients who underwent cardiopulmonary exercise testing. Outpatient CR was associated with improved outcomes after AMI, with greater benefit in patients with higher peak CPK. Myocardial injury severity may help identify patients most likely to benefit from CR.
No takes yet. Share an insight, caveat, or question.
Kataoka et al. (2026) conducted a cohort in Acute myocardial infarction survivors post-emergency PCI (n=535). Outpatient cardiac rehabilitation vs. Non-participation in cardiac rehabilitation was evaluated on Major adverse cardiovascular events (MACE), defined as all-cause death, recurrent myocardial infarction, or heart failure hospitalization (HR 0.23, 95% CI 0.14-0.81, p=0.01). Outpatient cardiac rehabilitation was associated with lower major cardiovascular events incidence after AMI compared with no rehabilitation, especially when peak CPK ≥2000 U/L.
Synapse has enriched 10 related papers. Consider them for comparative context: