Key result
Preventive cardiology must integrate upstream structural determinants, the exposome, and One Health with classical risk factor control to sustain real-world therapy and reduce health inequities.
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This perspective argues that effective preventive cardiology must move beyond controlling classical downstream risk factors to integrate upstream social and structural determinants, the life-course exposome, and the One Health framework to ensure sustainable real-world implementation and population resilience.
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Piñeiro et al. (2026) conducted an editorial in Cardiovascular disease prevention. Upstream determinants, the exposome, and One Health frameworks vs. Classical downstream risk factor management was evaluated. Preventive cardiology must integrate upstream structural determinants, the exposome, and One Health with classical risk factor control to sustain real-world therapy and reduce health inequities.
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