Key result
Epicardial adipose tissue drives obesity-related HFpEF, present as visceral adiposity in ~96% of patients.
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Epicardial adipose tissue actively contributes to the obesity-related HFpEF phenotype through both metabolic paracrine signaling and mechanical pericardial constraint.
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Đuzel et al. (2026) conducted a review in Heart failure with preserved ejection fraction (HFpEF) and obesity. Epicardial adipose tissue (EAT) / Visceral adiposity was evaluated. Epicardial adipose tissue actively contributes to obesity-related HFpEF through inflammation, fibrosis, and mechanical pericardial constraint, with 96% of HFpEF patients having visceral adiposity.
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