Dynamic Changes in High-Density Lipoprotein During Sepsis and Their Association with Organ Dysfunction.

Background: Sepsis is the second leading cause of mortality in the ICU. High-density lipoprotein has emerged as an important prognostic biomarker in sepsis. Beyond its established role in reverse cholesterol transport, HDL possesses anti-inflammatory, antioxidant, antiapoptotic, and immunomodulatory properties. HDL may contribute to the host response during sepsis, with its circulating levels potentially reflecting disease severity and clinical outcome. Changes in HDL concentrations may also provide valuable information regarding the inflammatory response and overall clinical course of patients with sepsis Methods: This prospective observational study was carried out on 40 adult patients presented to ICU with sepsis. Results: HDL levels increased significantly at the 3rd and 7th day compared to baseline. HDL showed a negative correlation with SOFA score on admission, at the 3rd and 7th day. HDL levels were higher in the survivors compared to non-survivors (p =0.015). Conclusion: There was a strong link between sepsis severity and serum HDL levels in the patients. Patients with severe sepsis and significant organ failure had low HDL levels.