Brain natriuretic peptide levels in patients with type 2 diabetes and atherosclerotic cardiovascular disease

Objective. To assess brain natriuretic peptide (BNP) levels in patients with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). Materials and Methods. The study included 92 patients with T2DM and a history of ASCVD, including 43 men and 49 women, with a mean age of 63.84 ± 10.6 years and a mean HbA1c level of 8.4 ± 2.61%. Patients were divided into 2 groups: Group 1 (n=43) – patients with T2DM and ASCVD and a history of vascular events; Group 2 (n=49) – patients with T2D and ASCVD, without a history of vascular events. Results. No correlation was found between BNP levels and the age of the patients (p > 0.05). A negative correlation was observed between BNP levels and left ventricular ejection fraction (LVEF) (r = -0.70; p < 0.001). In Group 1, the median BNP level was higher than in Group 2 – 26.8 and 21.9 pg/mL, respectively. Lower BNP levels were observed in obese patients (n = 55) – 20.4 pg/mL – compared with non-obese patients (n = 37) – 40.9 pg/mL (p < 0.05). Conclusion. A negative correlation between BNP and LVEF was found in patients with T2DM and ASCVD. Higher BNP levels were observed in T2DM patients with a history of vascular events. In obese patients, BNP levels were 2 times lower than in non-obese patients, regardless of age and the presence of a history of vascular events.