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The incorporation of machine learning (ML) into advanced healthcare informatics systems offers significant potential for revolutionising healthcare delivery, diagnosis and patient care. However, alongside the transformative potential, this synergy raises significant ethical considerations and challenges that demand thorough exploration. This research article delves into the multifaceted ethical landscape surrounding the implementation of ML in smart healthcare informatics. This study examines how ML technologies can either reinforce or disrupt these principles, with particular attention to issues of privacy, informed consent and data security. The potential for bias amplification in predictive models, especially in underrepresented patient populations, is a critical concern, and the ‘black-box’ nature of ML algorithms can hinder transparency and accountability, making it challenging for healthcare providers to justify treatment decisions to patients. Incorporating ML into smart healthcare informatics also raises questions about the equitable distribution of benefits and burdens. This article concludes by emphasising the need for a comprehensive ethical framework to guide the development and deployment of ML in healthcare. This study advocates for multidisciplinary collaboration among technologists, healthcare professionals, policymakers and ethicists to navigate these challenges effectively, fostering a healthcare ecosystem where ML serves as a valuable tool while upholding the highest ethical standards. Ultimately, the responsible and ethical implementation of ML in smart healthcare informatics has the potential to transform healthcare delivery, improving outcomes and enhancing patient trust and well-being.
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Sharma et al. (2026) studied this question.
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