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Run a fixed 4-send cap as the control; deploy adaptive only if incremental replies per extra opt-out meets your pre-launch value ratio. Require verified unsubs. Independent technical note mirroring the canonical version: https://mm-ais.com/blog/adaptive-vs-fixed-email-cadence-test-reply-lift-against-opt-out-break-even.php
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Claire Dawson (2026) studied this question.
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