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Background: Gingival inflammation is common during pregnancy. Chlorhexidine can reduce plaque and gingivitis but may cause local adverse effects, while cocoa contains bioactive compounds with potential oral activity.Objectives: To compare Gingival Index changes after 1% cocoa bean extract and 0.2% chlorhexidine mouthwashes in pregnant women with gingivitis.Methods: A two-group pretest–posttest study in Darul Imarah, Aceh Besar, included 100 pregnant women (50 per group). Participants rinsed with 20 mL for 30 seconds twice daily after toothbrushing for 14 days. Gingival Index scores were measured before and after use. Paired t tests assessed within-group changes and an independent t test compared change scores.Results: Scores decreased from 2.08 ± 0.39 to 0.78 ± 0.32 in the cocoa group (change, 1.30 ± 0.41; p < 0.001) and from 2.06 ± 0.36 to 1.05 ± 0.35 in the chlorhexidine group (change, 1.01 ± 0.38; p < 0.001). The reported between-group p value was 0.003.Conclusions: The cocoa group showed a larger 14-day reduction in Gingival Index scores. Clinical relevance and safety require confirmation with verified effect estimates, standardized formulation, rigorous allocation, and adverse-event assessment.
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Nuraskin et al. (2026) studied this question.
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