Role of Antibodies, Inflammatory Markers, and Echocardiographic Findings in Post-Acute Cardiopulmonary Symptoms After Sars-Cov-2 Infection

Matthew S. Durstenfeld; Michael J. Peluso; John Daniel Kelly; Sithu Win; Shreya Swaminathan; Danny Li; Victor M. Arechiga; Victor Zepeda; Kaiwen Sun; Shirley J. Shao; Christopher A. Hill; Mireya I. Arreguin; Scott Lu; Rebecca Hoh; Viva Tai; Ahmed Chenna; Brandon C. Yee; John William Winslow; Christos J. Petropoulos; John Kornak; Timothy J. Henrich; Jeffrey N. Martin; Steven G. Deeks; Priscilla Y. Hsue

doi:10.1016/s0735-1097(22)03099-6

Structured PICO

P

Population

102 adults >8 weeks after SARS-CoV-2 infection (median age 52, range 24-86; 41% women), assessed at a median of 7.2 months (IQR 4.1-9.1) after symptom onset; 47 reported dyspnea, chest pain, or palpitations

I

Intervention

Assessment of echocardiographic (TTE) parameters and cardiac/inflammatory biomarkers (SARS-CoV-2 receptor binding domain IgG antibodies, hsCRP, hs-troponin, NT-pro-BNP)

C

Comparator

Asymptomatic participants (55 participants without dyspnea, chest pain, or palpitations)

O

Outcome

Presence of post-acute cardiopulmonary symptoms (dyspnea, chest pain, or palpitations) at a median 7.2 months after symptom onsetpatient reported

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Implication

In adults with post-acute SARS-CoV-2 infection, persistent cardiopulmonary symptoms are associated with elevated inflammatory markers (hsCRP), SARS-CoV-2 antibody levels, and pericardial effusions rather than myocardial dysfunction or injury biomarkers.

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Cite This Study

Durstenfeld et al. (2022) studied this question.

synapsesocial.com/papers/6af9783c69d3ef063d6ebd55 https://doi.org/10.1016/s0735-1097(22)03099-6

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Role of Antibodies, Inflammatory Markers, and Echocardiographic Findings in Post-Acute Cardiopulmonary Symptoms After Sars-Cov-2 Infection

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Role of Antibodies, Inflammatory Markers, and Echocardiographic Findings in Post-Acute Cardiopulmonary Symptoms After Sars-Cov-2 Infection

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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