Key result
Multimodality imaging improves diagnostic accuracy and guides targeted therapy for secondary hypertension.
Why the study?
Secondary hypertension accounts for 5-15% of hypertension cases and stems from potentially curable endocrine or non-endocrine disorders that require early recognition. Diagnostic imaging plays a central role in identifying the underlying etiology, guiding treatment, and preventing long-term cardiovascular and renal complications.
A multimodality imaging approach tailored to clinical presentation and laboratory findings can improve diagnostic accuracy for uncovering the causes of secondary hypertension and facilitate timely, targeted intervention.
Answers are grounded in this paper and cite their sources.
Supports targeted use of multimodality imaging in secondary hypertension; leaves open the need for prospective validation before practice change.
Secondary hypertension accounts for approximately 5â"15% of hypertension cases and is caused by identifiable endocrine or non-endocrine disorders, many of which are potentially curable. Early recognition is essential, particularly in patients with resistant hypertension, young age at onset, or atypical clinical features. Diagnostic imaging plays a central role in identifying the underlying etiology, guiding treatment, and preventing long-term cardiovascular and renal complications. This review aimed to summarize the imaging characteristics of major causes of secondary hypertension, including primary aldosteronism, Cushing syndrome, pheochromocytoma and paraganglioma, thyroid disorders, renal parenchymal disease, renovascular hypertension, and vascular abnormalities such as coarctation of the aorta and mid-aortic syndrome. The strengths and limitations of ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine, and conventional angiography were considered, with emphasis on selecting the appropriate modality according to clinical presentation and laboratory findings. A multimodality imaging approach can improve diagnostic accuracy and facilitate timely, targeted intervention.
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Alqassimi et al. (2026) conducted a review in Secondary hypertension. Multimodality diagnostic imaging (ultrasonography, CT, MRI, nuclear medicine, and conventional angiography) was evaluated. Multimodality diagnostic imaging improves diagnostic accuracy and guides targeted therapy for secondary hypertension, which accounts for 5-15% of all hypertension cases.
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